1) Insert your USB Programming Cable.
Launch Device Manager.
[  Start  |  Right-click Computer  |  Select Properties  |  Device Manager  ]



3) Select: Ports (COM & LPT)


If there is a yellow warning triangle under ‘Ports’ or ‘Other Devices’, you have an incompatible driver and need to continue.

Prolific Prolific

If there is no yellow warning triangle, you have the correct driver and are ready to load your programming software.


        Your software will ask for this Com Port number later.
If you change USB ports, the Com Port number will also change.

Installing the Proper New Prolific PL-2303 Drivers

System Requires 32/64 bit  Windows Vista / 7 / 8 / 10

1) Create a new work Folder on your PC.

2) Download the Prolific driver file and save it to the work folder.

[Download]      Password : www.hamedsalami.com

3) Remove the USB programming cable from your PC.

4) Double-click the file that was saved into the work folder and follow the prompts until it is completely installed.

5) Plug the USB programming cable into the USB port of your PC.
You should see a balloon popup that says “Installing device driver software”


A few seconds later you will get a balloon popup that says
“Device driver software was not successfully installed”


6) Launch Device Manager.

[  Start  |  Right-click Computer  |  Properties  |  Device Manager  ]


You will see one of the following errors in Device Manager.

In ‘Other Devices’ the ‘USB-Serial Controller’ is proceeded by a YELLOW warning.



In ‘Ports (COM & LPT)’ the ‘Prolific USB-to-Serial Comm Port (COMx)’ is proceeded by a YELLOW warning.


7) Right-click on the entry with the error to open a window and select
“Update driver software…”


8) At the first Update Driver Software prompt, select
“Browse my computer for driver software”.


9) At the second Update Driver Software prompt, select
“Let me pick from a list of device drivers on my computer”


10) At the third Update Driver Software prompt, scroll down and select
“Ports (COM & LPT)”.


11) At the fourth Update Driver Software prompt, select
“Prolific USB-to-Serial Comm Port Version: [7/31/2007]”.


You should get a prompt saying that the driver was installed successfully.
You should now see a properly installed Prolific driver in Device Manger.


You can check that the correct version is installed by double-clicking on the Prolific entry in device manager and selecting the Driver tab.

The driver version shown should be v3.2.0.0


12) Remove the USB programming cable from your PC and then plug the USB programming cable back in.

13) (Optional) Reboot your computer.


About Hamed Salami

Just Another Networker,Certified Network Specialist with B.Sc. In Computer Engineering and Experience Of Advanced Networking Specialized. MTCNA,MTCWE,MTCTCE,MTCUME,MTCRE,MTCINE MCSA,MCSE 2012(Charter Member),MCITP ENterprise,Server Administrator,MCSA,MCSE 2003

12 Responses to Prolific Usb to Serial Driver Error Code 10
  1. I was able to find good info from your blog posts.

  2. This extremely great bog.

  3. You’re so cool! I do not suppose I’ve learned anything like this before.
    So nice to find anybody with some authentic thoughts on this subject.
    really thank you for starting this up. this web site is a thing that is desired online, someone with a little bit originality.
    useful job for bringing something totally new to the web!

  4. Great post! Keep it up.

  5. Thanks for this wonderful post, I am glad I found this website on google.

  6. Your’s is the inllteigent approach to this issue.

  7. Such a deep anwers! GD&RVVF

  8. Thank you very much. Your method works well. You have any email address??

  9. Thank you very much for your support
    after long time and struggle i got and it is working well

  10. Thanks, Hamed. Your post helped me over one of the Win 10 upgrade issues.

  11. Amazing info, Thanks a lot!

  12. If not, then the correct driver is not installed. Unplug the USB-To-Serial adapter and run the PL2303_Driver_Installer.exe again, following the directions until correct driver appears in Device Manager.


Leave a Reply

Your email address will not be published. Required fields are marked *